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KMID : 0363320120330040572
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Journal of Korean Oriental Internal Medicine
2012 Volume.33 No. 4 p.572 ~ p.586
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The Protective Effects of Sasim-tang on the Brain Cell Damage in Photothrombotic Ischemia Mouse Model
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Kang Baek-Gyu
Yun Jong-Min
Moon Byung-Soon
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Abstract
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Objectives : This study was designed to investigate the effects of Sasim-tang (SST) on proinflammatory cytokine production in a photothrombotic ischemia mouse model.
Methods : Photothrombotic ischemia was induced in stereotactically held male Balb/c mice using rose bengal (10 mg/kg) and cold light. The target of photothrombotic ischemic lesion was 1 mm anterior to bregma and 3 mm lateral to midline with 2 mm in diameter, which are decreased by oral administration of SST.
Results : SST protected ischemic death of brain cells through inhibition of pro-inflammatory cytokines production and catalytic activation of caspase-3 protease in photothrombotic ischemia mouse model.
Conclusions : The results of this study suggest that SST can have protective effects on brain cell damage in a photothrombotic ischemia mouse model.
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KEYWORD
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Sasim-tang (Xiexin-tang), photothrombotic ischemia, proinflammatory cytokine production
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